Ovarian Polycystic Induction with Morphine in Wistar Rat

ovarian polycystic induction with morphine in wistar rat

background and objective: the effect of opioids on the reproductive system has been studied as an attractive research field. in this study, the effect of morphine as an analgesic opioid was evaluated on the ovarian polycystic induction in the rat. materials & methods: in this study, 24 female virgin wistar rats weighing 200-250 g were injected with morphine (1-10 mg/kg/day) for 9 days. cont...

Protective effect of silver nano particles against ovarian polycystic induced by morphine in rat

Background and Objective: Morphine can cause harmful effects in the ovaries. The silver nanoparticles (Ag-NPs) used in health care because of antimicrobial properties, can diffuse into the brain blood barrier. This study investigated the protective effect of Ag-NPs on the induction of polycystic ovary (PCO) due to injection of morphine intra-ventromedial hypothalamus (intra-VMH) of rat compared...

P-207: Pharmacogenetic Study of CYP19A1 (Aromatase) in Ovarian Induction in Iranian Polycystic Ovarian Syndrome Patients

Background: Hyper-androgenemia is one of the main clinical features of polycystic ovarian syndrome (PCOS). Letrozol is an aromatase inhibitor drug, which is co-administered with gonadotropins in most cases of PCOS, to improve ovulation. Aromatase has a critical role in catalyzing the conversion of androgens to estrogens and is responsible for keeping the homeostatic balance between them. Hence ...

Nitric Oxide-Induced Polycystic Ovaries in The Wistar Rat

Effect of Grape Seed Extract on Lipid Profile and Expression of Interleukin-6 in Polycystic Ovarian Syndrome Wistar Rat Model

Objective Polycystic ovary syndrome (PCOS) is a common but complex endocrine disorder and is the major cause of anovulation and consequent subfertility. In this study effect of GSE on TG, TC, HDL-C, LDL-C and IL-6 in PCOS Wistar rats were assessed. MaterialsAndMethods : In this experimental study, 84 adult female Wistar rats were divided into 7 groups (n=12) including control(intact), Sham(estr...

Interaction of sulpiride with morphine in induction of male rat infertility

Introduction & Objective: Male fertility depends on the proper function of a complex system of organs. Harmful effects of morphine on male reproduction and fertility are well documented. Dopamine facilitates sexual behavior in different animal species. The antagonizing of dopamine D2 receptors with sulpiride was aimed to investigate the interaction of dopaminergic system with morphine-induced i...